Postinfarct intramyocardial injection of mesenchymal stem cells pretreated with TGF-α improves acute myocardial function
نویسندگان
چکیده
منابع مشابه
Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction.
Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate promising results, many practical and mechanistic issues regarding this therapy remain highly controversial. Here, we report the results of a randomized study of bone-marrow-derived mesenchymal stem cells, administered to pigs, which offer several new insights regarding cellular cardiomyoplasty. First, cells...
متن کاملEffects of mesenchymal stem cells with injectable scaffold on cardiac function in myocardial infarction in Rabbit
BACKGROUND: Bone marrow-derived mesenchymal cellscan transdifferentiate into Cardiomyocyte cells and improveheart function after transplantation. Since biomaterials canimprove the cell retention in the site, cell survival and differentiation,heart tissue engineering is now being explored as anapplied solution to support cell-based therapies and increasetheir efficacy for myocardial diseases. Ch...
متن کاملMesenchymal stem cell injection after myocardial infarction improves myocardial compliance.
Cellular therapy for myocardial injury has improved ventricular function in both animal and clinical studies, though the mechanism of benefit is unclear. This study was undertaken to examine the effects of cellular injection after infarction on myocardial elasticity. Coronary artery ligation of Lewis rats was followed by direct injection of human mesenchymal stem cells (MSCs) into the acutely i...
متن کاملTransplantation of Cardiogenic Pre-Differentiated Autologous Adipose-Derived Mesenchymal Stem Cells Induced by Mechanical Loading Improves Cardiac Function Following Acute Myocardial Infarction in Rabbit Model
Objective- Investigate myocardial performance after autologous adipose-derived (ASCs) mesenchymal stem cell differentiated under equiaxial cyclic strain, transplantation in rabbits with acute myocardial infarction (AMI). Design- Prospective, randomized experimental study Animals- 20 New Zealand White rabbits (2-3 kg) P...
متن کاملDirect intramyocardial injection of mesenchymal stem cell sheet fragments improves cardiac functions after infarction.
AIMS Cell transplantation is a promising approach for patients with myocardial infarction. However, following injection, retention of the transplanted cells in the injected area remains a central issue, which can be deleterious to cell transplantation therapy. We hypothesized that the use of cell sheet fragments, with the preservation of extracellular matrix (ECM), may significantly increase ce...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
سال: 2010
ISSN: 0363-6119,1522-1490
DOI: 10.1152/ajpregu.00084.2010